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Article

Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.

The Journal of biological chemistry - 3 Dec 2004

Nadauld Lincoln D, Sandoval Imelda T, Chidester Stephanie, Yost H Joseph, Jones David A

Abstract excerpt

Mutations in the APC (adenomatous polyposis coli) tumor suppressor gene cause uncontrolled proliferation and impaired differentiation of intestinal epithelial cells. Recent studies indicate that human colon adenomas and carcinomas lack retinol dehydrogenases (RDHs) and that APC regulates the expression of human RDHL. These data suggest a model wherein APC controls enterocyte differentiation by controlling...

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Identifiers

PMID: 15358764
DOI: 10.1074/jbc.M408830200

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.PMID 15358764Read ↗

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The Tumor Suppressor Adenomatous Polyposis Coli and Caudal Related Homeodomain Protein Regulate Expression of Retinol Dehydrogenase LSemantic proximity Read ↗

The Adenomatous Polyposis Coli Tumor Suppressor Gene Regulates Expression of Cyclooxygenase-2 by a Mechanism That Involves Retinoic AcidSemantic proximity Read ↗

Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases.Semantic proximity Read ↗

Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS FormationSemantic proximity Read ↗

Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli.Semantic proximity Read ↗

Retinoic acid signaling drives differentiation toward the absorptive lineage in colorectal cancerSemantic proximity Read ↗

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The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium.Semantic proximity Read ↗

CYP26A1 Links WNT and Retinoic Acid Signaling: A Target to Differentiate ALDH+ Stem Cells in APC-Mutant CRCSemantic proximity Read ↗

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.Semantic proximity Read ↗

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