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Article

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2008

Reed Karen R, Athineos Dimitris, Meniel Valerie S, Wilkins Julie A, Ridgway Rachel A, Burke Zoé D, Muncan Vanesa, Clarke Alan R, Sansom Owen J

Abstract excerpt

Dysregulated Wnt signaling is seen in approximately 30% of hepatocellular carcinomas; thus, finding pathways downstream of the activation of Wnt signaling is key. Here, using cre-lox technology, we deleted the Apc gene in the adult mouse liver and observed a rapid increase in nuclear beta-catenin...

Read the complete abstract on PubMed

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Share to Adenomatous Polyposis Coli Protein
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Mice, Transgenic

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Share to Proto-Oncogene Proteins c-myc

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Source

Open in PubMed Open full text

Identifiers

PMID: 19033191
DOI: 10.1073/pnas.0805778105
PMCID: PMC2596219

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19033191-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.PMID 19033191Read ↗

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Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas.Semantic proximity Read ↗

Myc deletion rescues Apc deficiency in the small intestine.Semantic proximity Read ↗

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The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.Semantic proximity Read ↗

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A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression.Semantic proximity Read ↗

Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/TazSemantic proximity Read ↗

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