Article
In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter.
PloS one - 1 Jan 2014
Mich John K, Payumo Alexander Y, Rack Paul G, Chen James K
Abstract excerpt
The Hedgehog (Hh) pathway is essential for embryonic development and tissue regeneration, and its dysregulation can lead to birth defects and tumorigenesis. Understanding how this signaling mechanism contributes to these processes would benefit from an ability to visualize Hedgehog pathway activity in live organisms, in real time, and with single-cell resolution. We report here the generation of transgenic...
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