Autoproteolysis in hedgehog protein biogenesis.

doi:10.1126/science.7985023

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Autoproteolysis in hedgehog protein biogenesis.

Science (New York, N.Y.) - 2 Dec 1994

Lee J J, Ekker S C, von Kessler D P, Porter J A, Sun B I, Beachy P A

Abstract excerpt

Extracellular signaling proteins encoded by the hedgehog (hh) multigene family are responsible for the patterning of a variety of embryonic structures in vertebrates and invertebrates. The Drosophila hh gene has now been shown to generate two predominant protein species that are derived by an internal autoproteolytic cleavage of a larger precursor. Mutations that reduced the efficiency of autoproteolysis in vitro...

Topics

Amino Acid Sequence
Animals
Cell Line
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Embryonic Induction
Gene Expression Regulation, Developmental
Genes, Insect
Hedgehog Proteins
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Precursors

Protein Processing, Post-Translational

Proteins

Serine Endopeptidases

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 7985023
DOI: 10.1126/science.7985023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7985023-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autoproteolysis in hedgehog protein biogenesis.PMID 7985023Read ↗

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.Semantic proximity Read ↗

The full-length unprocessed hedgehog protein is an active signaling molecule.Semantic proximity Read ↗

The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activitySemantic proximity Read ↗

Proteolytic cleavage of Notch: "HIT and RUN".Semantic proximity Read ↗

Extensive phosphorylation of Smoothened in Hedgehog pathway activation.Semantic proximity Read ↗

DHH pathogenic variants involved in 46,XY disorders of sex development differentially impact protein self-cleavage and structural conformation.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.Semantic proximity Read ↗

Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.Semantic proximity Read ↗

Dual degradation signals control Gli protein stability and tumor formation.Semantic proximity Read ↗

Protein splicing and related forms of protein autoprocessing.Semantic proximity Read ↗

Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryosSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.