Article
The full-length unprocessed hedgehog protein is an active signaling molecule.
The Journal of biological chemistry - 22 Jan 2010
Tokhunts Robert, Singh Samer, Chu Tehyen, D'Angelo Gisela, Baubet Valerie, Goetz John A, Huang Zhen, Yuan Ziqiang, Ascano Manuel, Zavros Yana, Thérond Pascal P, Kunes Sam, Dahmane Nadia, Robbins David J
Abstract excerpt
The hedgehog (HH) family of ligands plays an important instructional role in metazoan development. HH proteins are initially produced as approximately 45-kDa full-length proteins, which undergo an intramolecular cleavage to generate an amino-terminal product that subsequently becomes cholesterol-modified (HH-Np). It is well accepted that this cholesterol-modified amino-terminal cleavage product is responsible for...
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