Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.

Blood - 1 Sept 2008

Chae Jae Jin, Wood Geryl, Richard Katharina, Jaffe Howard, Colburn Nona T, Masters Seth L, Gumucio Deborah L, Shoham Nitza G, Kastner Daniel L

Abstract excerpt

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in MEFV, which encodes a 781-amino acid protein denoted pyrin. We have previously shown that pyrin regulates caspase-1 activation and IL-1beta production through interaction of its N-terminal PYD motif with the ASC adapter protein, and also modulates IL-1beta production by interaction of its C-terminal B30.2 domain with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calpain
Share to Caspase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colchicine

Share to Familial Mediterranean Fever

Share to I-kappa B Proteins

Share to NF-KappaB Inhibitor alpha

Share to Transcription Factor RelA

Source

Open in PubMed Open full text

Identifiers

PMID: 18577712
DOI: 10.1182/blood-2008-01-134932
PMCID: PMC2518886

Genes

MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.PMID 18577712Read ↗

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.Semantic proximity Read ↗

Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.Semantic proximity Read ↗

The immunological function of familial Mediterranean fever disease protein PyrinSemantic proximity Read ↗

Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns.Semantic proximity Read ↗

A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.Semantic proximity Read ↗

Complex formation dynamics of native and mutated pyrin's B30.2 domain with caspase-1.Semantic proximity Read ↗

Dysregulated production of interleukin-1β upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever.Semantic proximity Read ↗

The PRY/SPRY Domain of Pyrin/TRIM20, The Familial Mediterranean Fever Protein, Interacts with β2-Microglobulin to Promote Inflammasome FormationSemantic proximity Read ↗

[The role of interleukin-1 and interleukin-1-receptor antagonist in development of familial mediterranean fever and other autoinflammatory diseases].Semantic proximity Read ↗

Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome AssemblySemantic proximity Read ↗

NLRP1 inflammasome drives IL-18 in Familial Mediterranean Fever and MEFV variantsSemantic proximity Read ↗

Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.