Article

NLRP1 inflammasome drives IL-18 in Familial Mediterranean Fever and MEFV variants

2025-12-22

Abstract excerpt

<title>Abstract</title> <p>“Familial Mediterranean Fever (FMF) (OMIM #249100) is the most prevalent hereditary autoinflammatory disease globally, though it remains rare outside Mediterranean populations. FMF is caused by gain-of-function mutations in the MEFV gene, which encodes the immune regulatory protein pyrin. Recent studies suggest that multiple inflammasomes, including the pyrin inflammasome, may work syne...

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Literature Corpus work: 212d1695-9416-50bc-8dc9-f9efc0ccd892
DOI: 10.21203/rs.3.rs-7037096/v1

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