Article

The PRY/SPRY Domain of Pyrin/TRIM20, The Familial Mediterranean Fever Protein, Interacts with β2-Microglobulin to Promote Inflammasome Formation

2021-02-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Pyrin/TRIM20 is expressed in the neutrophils and monocytes/macrophages and regulates caspase-1 activation and interleukin-1β maturation. Although the mutations in the PRY/SPRY domain of pyrin cause familial Mediterranean fever (FMF), the mechanism of how mutated pyrin provokes excessive inflammation in FMF patients is not well understood. This study was undertak...

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Literature Corpus work: 36912db6-bbeb-5960-a989-eeca48cc759f
DOI: 10.21203/rs.3.rs-212639/v1

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