Article
Dysregulated production of interleukin-1β upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever.
Human immunology - 1 Jul 2015
Repa Argyro, Bertsias George K, Petraki Eleni, Choulaki Christianna, Vassou Despoina, Kambas Konstantinos, Boumpas Dimitrios T, Goulielmos George, Sidiropoulos Prodromos
Abstract excerpt
Familial Mediterranean fever (FMF) is caused by mutations in pyrin, a protein expressed in innate immune cells that interacts with caspase-1 and other inflammasome components to regulate interleukin (IL)-1β maturation. Since NLRP3 inflammasome represents major source of IL-1β, we studied its protein expression and function in FMF. We isolated peripheral white blood cells (WBCs) from 20 symptoms-free FMF patients...
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