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Article

Complex formation dynamics of native and mutated pyrin's B30.2 domain with caspase-1.

Proteins - 1 Jun 2018

Arakelov Grigor, Arakelov Vahram, Nazaryan Karen

Abstract excerpt

Pyrin protein is the product of the MEFV gene, mutations in which cause manifestation of familial Mediterranean fever (FMF). Functions of pyrin are not completely clear. The secondary structure of the pyrin is represented with four domains and two motifs. Mutations p.M680I, p.M694V, p.M694I, p.K695R, p.V726A, and p.A744S, which are located in the B30.2 domain of pyrin protein, are responsible for manifestation of...

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Source

Identifiers

PMID: 29575132
DOI: 10.1002/prot.25494

Genes

MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complex formation dynamics of native and mutated pyrin's B30.2 domain with caspase-1.PMID 29575132Read ↗

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