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Article

The immunological function of familial Mediterranean fever disease protein Pyrin

11 Oct 2014

Abstract excerpt

Pyrin, encoded by MEFV gene, is conserved in humans and mice. Mutations in the MEFV gene are associated with the human autoinflammatory disease familial Mediterranean fever (FMF). Pyrin can interact with the inflammasome adaptor ASC and induce inflammatory caspase-1 activation in monocytic cells, but the physiological function of Pyrin has been unknown for many years. Here we summarize previous studies of Pyrin...

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PMID: 25307949
DOI: 10.1007/s11427-014-4758-3

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