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Article

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2006

Chae Jae Jin, Wood Geryl, Masters Seth L, Richard Katharina, Park Grace, Smith Brian J, Kastner Daniel L

Abstract excerpt

Familial Mediterranean fever (FMF) is a recessively inherited autoinflammatory disorder with high carrier frequencies in the Middle East. Pyrin, the protein mutated in FMF, regulates caspase-1 activation and consequently IL-1beta production through cognate interaction of its N-terminal PYRIN motif with the ASC adaptor protein. However, the preponderance of mutations reside in pyrin's C-terminal B30.2 domain. Here...

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Identifiers

PMID: 16785446
DOI: 10.1073/pnas.0602081103
PMCID: PMC1479864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.PMID 16785446Read ↗

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