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Article

Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.

Journal of cellular physiology - 1 Sept 2008

Balci-Peynircioglu Banu, Waite Andrea L, Hu Chunbo, Richards Neil, Staubach-Grosse Ann, Yilmaz Engin, Gumucio Deborah L

Abstract excerpt

Mutations in pyrin cause the autoinflammatory disorder familial Mediterranean fever (FMF), a syndrome characterized by sporadic and unpredictable attacks of fever and localized severe pain. Currently, it is not clear how attacks are triggered, nor why they spontaneously resolve after 2 or 3 days. In fact, the cellular function of the pyrin protein and the molecular underpinnings of its malfunction in FMF have so...

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Source

Identifiers

PMID: 18330885
DOI: 10.1002/jcp.21435

Genes

MEFV
PSTPIP1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.PMID 18330885Read ↗

The role of the pro-apoptotic protein Siva in the pathogenesis of Familial Mediterranean fever: A structural and functional analysis.Semantic proximity Read ↗

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.Semantic proximity Read ↗

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.Semantic proximity Read ↗

The immunological function of familial Mediterranean fever disease protein PyrinSemantic proximity Read ↗

A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.Semantic proximity Read ↗

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.Semantic proximity Read ↗

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.Semantic proximity Read ↗

Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns.Semantic proximity Read ↗

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation.Semantic proximity Read ↗

Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome AssemblySemantic proximity Read ↗

The pyrin inflammasome and the Yersinia effector interaction.Semantic proximity Read ↗

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.Semantic proximity Read ↗

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