Article
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 2008
Joosten Leo A B, Heinhuis Bas, Abdollahi-Roodsaz Shahla, Ferwerda Gerben, Lebourhis Lionel, Philpott Dana J, Nahori Marie-Anne, Popa Calin, Morre Servaas A, van der Meer Jos W M, Girardin Stephen E, Netea Mihai G, van den Berg Wim B
Abstract excerpt
The pathogenesis of chronic joint inflammation remains unclear, although the involvement of pathogen recognition receptors has been suggested recently. In the present article, we describe the role of two members of the NACHT-LRR (NLR) family, Nod1 (nucleotide-binding oligomerization domain) and Nod2 in a model of acute joint inflammation induced by intraarticular injection of Streptococcus pyogenes cell wall...
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