Article
NOD-like receptors and inflammation.
Arthritis research & therapy - 1 Jan 2008
Mathews Rebeccah J, Sprakes Michael B, McDermott Michael F
Abstract excerpt
The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases, as well as some more common polygenic conditions. Bacterial wall constituents and other cellular stressor...
Topics
- Animals
- Humans
- Inflammation Mediators
- Mutation
- Nod Signaling Adaptor Proteins
- Signal Transduction