Article
Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis.
Rheumatology (Oxford, England) - 1 May 2013
Plantinga Theo S, Fransen Jaap, Knevel Rachel, Netea Mihai G, Zwerina Jochen, Helsen Monique M A, van der Meer Jos W M, van Riel Piet L, Schett Georg, van der Helm-van Mil Annette H M, van den Berg Wim B, Joosten Leo A B
Abstract excerpt
OBJECTIVE: One of the disease hallmarks of RA is progressive cartilage and bone destruction in the joints. The exact mechanism underlying this disease process is largely unknown. Nod1, an intracellular pattern recognition receptor expressed by the innate immune system, has been previously shown to display anti-inflammatory effects in experimental arthritis. Furthermore, an insertion/deletion polymorphism in NOD1...
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