Article
The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin.
Mutation research - 8 Jan 2008
Chakravarti Dhrubajyoti, Venugopal Divya, Mailander Paula C, Meza Jane L, Higginbotham Sheila, Cavalieri Ercole L, Rogan Eleanor G
Abstract excerpt
Polycyclic aromatic hydrocarbons (PAH) form stable and depurinating DNA adducts in mouse skin to induce preneoplastic mutations. Some mutations transform cells, which then clonally expand to establish tumors. Strong clues about the mutagenic mechanism can be obtained if the PAH-DNA adducts can be correlated with both preneoplastic and tumor mutations. To this end, we studied mutagenesis in PAH-treated early...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Base Sequence
- Benzopyrenes
- Carcinogens
- DNA Adducts
- Female
- Genes, ras
- Mice
- Mice, Inbred SENCAR
- Models, Genetic
- Mutation
- Papilloma
- Polycyclic Aromatic Hydrocarbons