Article
Mutation of KCNK5 or Kir3.2 potassium channels in mice does not change minimum alveolar anesthetic concentration.
Anesthesia and analgesia - 1 May 2003
Gerstin Karin M, Gong Diane H, Abdallah Mona, Winegar Bruce D, Eger Edmond I, Gray Andrew T
Abstract excerpt
UNLABELLED: Several reports suggest that clinically used concentrations of inhaled anesthetics can increase conductance through noninactivating potassium channels and that the resulting hyperpolarization might decrease excitability, thereby leading to the anesthetic state. We speculated that animals deficient in such potassium channels might be resistant to the effects of anesthetics. Thus, in the present study,...
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