Article
A mouse model of the slow channel myasthenic syndrome: Neuromuscular physiology and effects of ephedrine treatment.
Experimental neurology - 1 Oct 2013
Webster R G, Cossins J, Lashley D, Maxwell S, Liu W W, Wickens J R, Martinez-Martinez P, de Baets M, Beeson D
Abstract excerpt
In the slow channel congenital myasthenic syndrome mutations in genes encoding the muscle acetylcholine receptor give rise to prolonged ion channel activations. The resulting cation overload in the postsynaptic region leads to damage of synaptic structures, impaired neuromuscular transmission and fatigable muscle weakness. Previously we identified and characterised in detail the properties of the slow channel...
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