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Article

Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity.

Free radical biology & medicine - 1 Jan 2012

Jensen Annie, Løhr Mille, Eriksen Louise, Grønbæk Morten, Dorry Elad, Loft Steffen, Møller Peter

Abstract excerpt

Oxidatively damaged DNA base lesions are considered to be mainly repaired by 8-oxoguanine DNA glycosylase (OGG1) mediated pathways. We investigated the effect of the OGG1 Ser326Cys polymorphism on the level and repair of oxidatively damaged DNA in mononuclear blood cells (MNBC) by means of the comet assay. We collected blood samples from 1,019 healthy subjects and genotyped for the OGG1 Ser326Cys polymorphism. We...

Topics

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Adenocarcinoma of Lung
Comet Assay
Denmark
DNA Glycosylases
Guanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Oxidation-Reduction

Oxidative Stress

Source

Identifiers

PMID: 22019439
DOI: 10.1016/j.freeradbiomed.2011.09.038

Genes

OGG1
ERCC1
MUTYH
NEIL1
NUDT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity.PMID 22019439Read ↗

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DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.Semantic proximity Read ↗

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A systematic review and meta-analysis of the association between OGG1 Ser326Cys polymorphism and cancers.Semantic proximity Read ↗

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