Article
Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention.
Free radical biology & medicine - 20 Aug 2018
Baptiste Beverly A, Katchur Steven R, Fivenson Elayne M, Croteau Deborah L, Rumsey William L, Bohr Vilhelm A
Abstract excerpt
The common oxidatively generated lesion, 8-oxo-7,8-dihydroguanine (8-oxoGua), is removed from DNA by base excision repair. The glycosylase primarily charged with recognition and removal of this lesion is 8-oxoGuaDNA glycosylase 1 (OGG1). When left unrepaired, 8-oxodG alters transcription and is mutagenic. Individuals homozygous for the less active OGG1 allele, Ser326Cys, have increased risk of several cancers....
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