A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population.

doi:10.1371/journal.pone.0089662

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Article

A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population.

PloS one - 1 Jan 2014

Shen Huanxi, Cao Jinglian, Hong Zhiqiang, Liu Kai, Shi Jian, Ding Lu, Zhang Hengdong, Du Cheng, Li Qian, Zhang Zhengdong, Zhu Baoli

Abstract excerpt

DNA damage to cochlear hair cells caused by 8-oxoguanine (8-oxoG) is essential for the development of noise-induced hearing loss (NIHL). Human 8-oxoG DNA glycosylase1 (hOGG1) is a key enzyme in the base excision repair (BER) pathway that eliminates 8-oxoG. Many epidemiological and functional studies have suggested that the hOGG1 Ser326Cys polymorphism (rs1052133) is associated with many diseases. The purpose of...

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PMID: 24599382
DOI: 10.1371/journal.pone.0089662
PMCID: PMC3943766

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