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Genetic polymorphism in hOGG1 is associated with triple-negative breast cancer risk in Chinese Han women.

Breast (Edinburgh, Scotland) - 1 Oct 2013

Xie Hui, Xia Kai, Rong Hui, Chen Xiaoxiang

Abstract excerpt

8-hydroxy-2'-deoxyguanine (8-OHdG), a typical product of oxidative stress-induced DNA damage, can cause a G-T transversion during DNA replication if it is not removed. Human 8-oxoguanine glycosylase 1 (hOGG1), a key DNA repair gene, recognizes and excises 8-OHdG from damaged DNA accurately; however, a c.977C>G (Ser326Cys) polymorphism in hOGG1 can inhibit the gene's ability to remove 8-OHdG. The aim of present...

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PMID: 23369609
DOI: 10.1016/j.breast.2012.12.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Genetic polymorphism in hOGG1 is associated with triple-negative breast cancer risk in Chinese Han women.PMID 23369609Read ↗

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