Article
Evaluation of choline acetyltransferase gene polymorphism (2384 G/A) in Alzheimer's disease and mild cognitive impairment.
Dementia and geriatric cognitive disorders - 1 Jan 2008
Tang Muni, Rao Dongping, Ma Cui, Guo Yangbo, Han Haiying, Ling Kangguang, Ling Yuhua
Abstract excerpt
BACKGROUND/AIMS: It has been hypothesized that choline acetyltransferase (ChAT) activity might be associated with cognitive impairment in Alzheimer's disease (AD). A functional single nucleotide polymorphism (2384 G/A) of ChAT was proposed to be associated with AD risk and age of onset. The aim of this study was to evaluate this polymorphism in a cohort of Chinese AD patients and patients with mild cognitive...
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