Article
Choline acetyltransferase G +4 A polymorphism confers a risk for Alzheimer's disease in concert with Apolipoprotein E epsilon4.
Neuroscience letters - 12 Aug 2004
Kim Ki-Woong, Suh Young-Ju, Park Woong-Yang, Jhoo Jin-Hyeong, Lee Dong-Young, Youn Jong-Chul, Lee Kwang-Hyuck, Seo Jeong-Sun, Woo Jong-Inn
Abstract excerpt
To examine whether the single nucleotide polymorphism at position +4 of the choline acetyltransferase (ChAT) confers a risk for Alzheimer's disease (AD), we determined the ChAT and the Apolipoprotein (APOE) genotypes of the 246 AD patients and 561 non-demented controls. The ChAT AA genotype was found to confer the risk for AD in concert with the APOE epsilon4 by stochastic search variable selection (SSVS)...
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