ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease.

doi:10.1016/j.cca.2005.12.037

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Article

ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease.

Clinica chimica acta; international journal of clinical chemistry - 1 Jun 2006

Ahn Jo Sangmee, Ahn Kyungsook, Kim Ji-Hyun, Kang Byung-Hak, Kim Eunkyung, Jo Inho, Kim Doh Kwan

Abstract excerpt

BACKGROUND: One of the characteristic features of Alzheimer's disease (AD) is the degeneration of the cholinergic system. The gene encoding choline acetyltransferase (ChAT), a key enzyme in cholinergic function, is a candidate gene conferring risk for AD. But the genetic association of the enzyme with AD has been controversial. We analyzed 2 ChAT single nucleotide polymorphisms (SNPs), 2384G>A (rs3810950;...

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PMID: 16480703
DOI: 10.1016/j.cca.2005.12.037

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