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Article

Genetic variation in the choline O-acetyltransferase gene in depression and Alzheimer's disease: the VITA and Milano studies.

Journal of psychiatric research - 1 Sept 2011

Grünblatt Edna, Reif Andreas, Jungwirth Susanne, Galimberti Daniela, Weber Heike, Scarpini Elio, Sauer Cathrin, Wichart Ildiko, Rainer Michael K, Huber Klaus, Danielczyk Walter, Tragl Karl H, Deckert Jürgen, Fischer Peter, Riederer Peter

Abstract excerpt

Linkage studies point to the long arm of chromosome 10 being a susceptibility region for Alzheimer's disease (AD). Additionally, the gene choline O-acetyltransferase (CHAT) located on chromosome 10 was discussed for conveying risk towards AD, but the results are ambiguous. We examined a possible association of nineteen single-nucleotide polymorphisms (SNPs) in the CHAT gene in a longitudinal cohort study, the...

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Source

Identifiers

PMID: 21507424
DOI: 10.1016/j.jpsychires.2011.03.017

Genes

CHAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the choline O-acetyltransferase gene in depression and Alzheimer's disease: the VITA and Milano studies.PMID 21507424Read ↗

Genetic variants in the choline acetyltransferase (ChAT) gene are modestly associated with normal cognitive function in the elderly.Semantic proximity Read ↗

Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease.Semantic proximity Read ↗

CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer's disease in the Czech population.Semantic proximity Read ↗

Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer's Disease Risk: A Meta-Analysis.Semantic proximity Read ↗

Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study.Semantic proximity Read ↗

Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer's Disease: A Meta-Analysis.Semantic proximity Read ↗

Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease.Semantic proximity Read ↗

Choline acetyltransferase 2384G>a polymorphism and the risk of Alzheimer disease.Semantic proximity Read ↗

Investigation of association of serotonin transporter and monoamine oxidase-A genes with Alzheimer's disease and depression in the VITA study cohort: a 90-month longitudinal study.Semantic proximity Read ↗

Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease.Semantic proximity Read ↗

Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease.Semantic proximity Read ↗

ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease.Semantic proximity Read ↗

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