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Article

CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer's disease in the Czech population.

Journal of biomedical science - 14 May 2018

Hálová Alice, Janoutová Jana, Ewerlingová Laura, Janout Vladimír, Bonczek Ondřej, Zeman Tomáš, Gerguri Tereza, Balcar Vladimir J, Šerý Omar

Abstract excerpt

BACKGROUND: Cholinergic hypothesis of Alzheimer's disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with Alzheimer's disease. The hypothesis resulted in the development of centrally-acting agents potentiating cholinergic neurotransmission; these drugs, however, only slowed down the cognitive...

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Source

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Identifiers

PMID: 29759072
DOI: 10.1186/s12929-018-0444-2
PMCID: PMC5950140

Genes

CHAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer's disease in the Czech population.PMID 29759072Read ↗

Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer's Disease: A Meta-Analysis.Semantic proximity Read ↗

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Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer's Disease Risk: A Meta-Analysis.Semantic proximity Read ↗

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ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease.Semantic proximity Read ↗

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Meta-analyses of 8 polymorphisms associated with the risk of the Alzheimer's disease.Semantic proximity Read ↗

Association of CHAT Gene Polymorphism rs3793790 and rs2177370 with Donepezil Response and the Risk of Alzheimer's Disease Continuum.Semantic proximity Read ↗

Choline acetyltransferase G +4 A polymorphism confers a risk for Alzheimer's disease in concert with Apolipoprotein E epsilon4.Semantic proximity Read ↗

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