Article
Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability.
Molecular biology of the cell - 1 Sept 2008
Meadows John C, Millar Jonathan
Abstract excerpt
It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast. However, we show that Delta mto1 cells, which are defective in nucleation of cytoplasmic microtubules, have profoundly misoriented spindles but are not delayed in the timing of sister chromatid separation, providing compelling evidence that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.