Article
A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loads.
Journal of virology - 1 Sept 2008
Prestwood Tyler R, Prigozhin Daniil M, Sharar Kristin L, Zellweger Raphaël M, Shresta Sujan
Abstract excerpt
The four serotypes of dengue virus (DENV1 to DENV4) cause extensive morbidity and mortality. A major obstacle to studying disease pathogenesis and developing therapies has been the lack of a small-animal model. We previously reported isolation of a DENV2 strain, obtained by passaging a clinical isolate between mosquito cells and mice, that caused severe DENV disease in mice and contained multiple mutations,...
Topics
- Animals
- Dengue Virus
- Heparitin Sulfate
- Mice
- Mutation
- Serotyping
- Severe Dengue
- Severity of Illness Index
- Specific Pathogen-Free Organisms
- Tumor Necrosis Factor-alpha
- Viral Load
- Viral Proteins