Article
Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice.
Virology - 10 Oct 2000
Bernard K A, Klimstra W B, Johnston R E
Abstract excerpt
The arbovirus, Venezuelan equine encephalitis virus (VEE), causes disease in humans and equines during periodic outbreaks. A murine model, which closely mimics the encephalitic form of the disease, was used to study mechanisms of attenuation. Molecularly cloned VEE viruses were used: a virulent, epizootic, parental virus and eight site-specific glycoprotein mutants derived from the parental virus. Four of these...
Topics
- Animals
- CHO Cells
- Cricetinae
- Encephalitis Virus, Venezuelan Equine
- Female
- Heparin
- Heparitin Sulfate
- Mice
- Mutation
- Phenotype
- Structure-Activity Relationship