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Article

Dengue virus 3 genotype I shows natural changes in heparan sulphate binding sites, cell interactions, and neurovirulence in a mouse model.

The Journal of general virology - 1 Aug 2021

Andrade Adriana S, Ferreira Rafaela S, Guedes Maria Isabel M C, Dias Jamile, Pinheiro Mariana A, Arias Nidia Esther C, Reis Erik V S, de Souza Fernanda G, Kroon Erna G

Abstract excerpt

Dengue virus (DENV) is the most prevalent pathogen of the Flaviviridae family. Due to the considerable increase in DENV incidence and spread, symptoms such as CNS involvement have increased. Heparan sulphate (HS) was the first molecule identified as an adhesion factor for DENV in mammalian cells. Viral phenotypes with different HS interactions are associated with various clinical symptoms, including neurological...

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PMID: 34342561
DOI: 10.1099/jgv.0.001630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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