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Higher‐temperature‐adapted dengue virus serotype 2 strain exhibits enhanced virulence in AG129 mouse model

30 Jun 2023

Abstract excerpt

The factors that drive dengue virus (DENV) evolution, and selection of virulent variants are yet not clear. Higher environmental temperature shortens DENV extrinsic incubation period in mosquitoes, increases human transmission, and plays a critical role in outbreak dynamics. In the present study, we looked at the effect of temperature in altering the virus virulence. We found that DENV cultured at a higher...

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PMID: 37389962
DOI: 10.1096/fj.202300098r

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