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Article

Relative contribution of nonstructural protein 1 in dengue pathogenesis

14 May 2020

Abstract excerpt

Dengue is a major public health concern in the tropical and subtropical world, with no effective treatment. The controversial live attenuated virus vaccine Dengvaxia has boosted the pursuit of subunit vaccine approaches, and nonstructural protein 1 (NS1) has recently emerged as a promising candidate. However, we found that NS1 immunization or passive transfer of NS1 antibodies failed to confer protection in...

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PMID: 32584412
DOI: 10.1084/jem.20191548

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