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Article

Dengue type four viruses with E-Glu345Lys adaptive mutation from MRC-5 cells induce low viremia but elicit potent neutralizing antibodies in rhesus monkeys.

PloS one - 1 Jan 2014

Lin Hsiao-Han, Lee Hsiang-Chi, Li Xiao-Feng, Tsai Meng-Ju, Hsiao Hung-Ju, Peng Jia-Guan, Sue Shih-Che, Qin Cheng-Feng, Wu Suh-Chin

Abstract excerpt

Knowledge of virulence and immunogenicity is important for development of live-attenuated dengue vaccines. We previously reported that an infectious clone-derived dengue type 4 virus (DENV-4) passaged in MRC-5 cells acquired a Glu345Lys (E-E345K) substitution in the E protein domain III (E-DIII). The same cloned DENV-4 was found to yield a single E-Glu327Gly (E-E327G) mutation after passage in FRhL cells and...

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Identifiers

PMID: 24959738
DOI: 10.1371/journal.pone.0100130
PMCID: PMC4069063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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