Article
Conserved footprints of APOBEC3G on Hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences.
Journal of virology - 1 Sept 2008
Armitage Andrew E, Katzourakis Aris, de Oliveira Tulio, Welch John J, Belshaw Robert, Bishop Kate N, Kramer Beatrice, McMichael Andrew J, Rambaut Andrew, Iversen Astrid K N
Abstract excerpt
The human polynucleotide cytidine deaminases APOBEC3G (hA3G) and APOBEC3F (hA3F) are antiviral restriction factors capable of inducing extensive plus-strand guanine-to-adenine (G-to-A) hypermutation in a variety of retroviruses and retroelements, including human immunodeficiency virus type 1 (HIV-1). They differ in target specificity, favoring plus-strand 5'GG and 5'GA dinucleotide motifs, respectively. To...
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