Article
Variable contexts and levels of hypermutation in HIV-1 proviral genomes recovered from primary peripheral blood mononuclear cells.
Virology - 20 Jun 2008
Kijak Gustavo H, Janini Luiz Mario, Tovanabutra Sodsai, Sanders-Buell Eric, Arroyo Miguel Angel, Robb Merlin L, Michael Nelson L, Birx Debora L, McCutchan Francine E
Abstract excerpt
APOBEC-mediated cytidine deamination of HIV-1 genomes during reverse transcription has been shown to be a potent mechanism of host restriction for HIV-1 infection ex vivo and in vitro. However, this defense system can be overcome by the viral protein Vif. Unlike other mechanisms of host restriction, the APOCEC-Vif interaction leaves an imprint on integrated proviruses in the form of G-->A hypermutation. In the...
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