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Article

Variable contexts and levels of hypermutation in HIV-1 proviral genomes recovered from primary peripheral blood mononuclear cells.

Virology - 20 Jun 2008

Kijak Gustavo H, Janini Luiz Mario, Tovanabutra Sodsai, Sanders-Buell Eric, Arroyo Miguel Angel, Robb Merlin L, Michael Nelson L, Birx Debora L, McCutchan Francine E

Abstract excerpt

APOBEC-mediated cytidine deamination of HIV-1 genomes during reverse transcription has been shown to be a potent mechanism of host restriction for HIV-1 infection ex vivo and in vitro. However, this defense system can be overcome by the viral protein Vif. Unlike other mechanisms of host restricti...

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Identifiers

PMID: 18436274
DOI: 10.1016/j.virol.2008.03.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18436274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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