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Article

Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.

PLoS pathogens - 1 Jul 2014

Kim Eun-Young, Lorenzo-Redondo Ramon, Little Susan J, Chung Yoon-Seok, Phalora Prabhjeet K, Maljkovic Berry Irina, Archer John, Penugonda Sudhir, Fischer Will, Richman Douglas D, Bhattacharya Tanmoy, Malim Michael H, Wolinsky Steven M

Abstract excerpt

Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition. As an intrinsic antiretroviral defense mechanism, APOBEC3 proteins induce extensive guanosine-to-adenosine (G-to-A) mutagenesis and inhibit synthesis of nascent human immunodeficiency virus-type 1 (HIV-1) cDNA. Human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25080100
DOI: 10.1371/journal.ppat.1004281
PMCID: PMC4117599

Genes

APOBEC3D
APOBEC3F
APOBEC3G
APOBEC3H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.PMID 25080100Read ↗

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