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Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles

10 Jan 2023

Abstract excerpt

APOBEC3 (A3) proteins are host-encoded deoxycytidine deaminases that provide an innate immune barrier to retroviral infection, notably against HIV-1. Low levels of deamination are believed to contribute to the genetic evolution of HIV-1, while intense catalytic activity of these proteins can induce catastrophic hypermutation in proviral DNA leading to near-total HIV-1 restriction. So far, little is known about...

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PMID: 36627271
DOI: 10.1038/s41467-022-35379-y

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