Article
APOBEC3G and APOBEC3F rarely co-mutate the same HIV genome.
Retrovirology - 20 Dec 2012
Ebrahimi Diako, Anwar Firoz, Davenport Miles P
Abstract excerpt
BACKGROUND: The human immune proteins APOBEC3G and APOBEC3F (hA3G and hA3F) induce destructive G-to-A changes in the HIV genome, referred to as 'hypermutation'. These two proteins co-express in human cells, co-localize to mRNA processing bodies and might co-package into HIV virions. Therefore they are expected to also co-mutate the HIV genome. Here we investigate the mutational footprints of hA3G and hA3F in a...
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