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Article

Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis.

The Journal of biological chemistry - 11 May 2007

Liu Chao, Fei Erkang, Jia Nali, Wang Hongfeng, Tao Ruisong, Iwata Atsushi, Nukina Nobuyuki, Zhou Jiangning, Wang Guanghui

Abstract excerpt

alpha-Synuclein (alpha-syn) and ubiquitin (Ub) are major protein components deposited in Lewy bodies (LBs) and Lewy neurites, which are pathologic hallmarks of idiopathic Parkinson disease (PD). Almost 90% of alpha-syn in LBs is phosphorylated at serine 129 (Ser(129)). However, the role of Ser(12...

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PMID: 17360705
DOI: 10.1074/jbc.M700422200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17360705-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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