Article
Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.
Cells - 18 Nov 2022
Lassen Louise Berkhoudt, Thomsen Maj Schneider, Basso Elisa, Füchtbauer Ernst-Martin, Füchtbauer Annette, Outeiro Tiago Fleming, Jensen Poul Henning, Moos Torben
Abstract excerpt
Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in Drosophila. Here, we hypothesized that tyrosine mutations would similarly lead to impaired motor performance with neuropathology in a rodent model. In transgenic mice (ASO), tyrosines at positions 125, 133, and 136 in human α-synuclein were mutated to...
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