Article
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.
The Journal of experimental medicine - 7 Jul 2008
Willcocks Lisa C, Lyons Paul A, Clatworthy Menna R, Robinson James I, Yang Wanling, Newland Stephen A, Plagnol Vincent, McGovern Naomi N, Condliffe Alison M, Chilvers Edwin R, Adu Dwomoa, Jolly Elaine C, Watts Richard, Lau Yu Lung, Morgan Ann W, Nash Gerard, Smith Kenneth G C
Abstract excerpt
Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been associated with systemic lupus erythematosus (SLE). FcgammaRIIIb is a glycosylphosphatidylinositol-linked, low affinity receptor for IgG found predominantly on human neutrophils. We present novel data demonstrating...
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