Article
Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.
Human mutation - 1 Apr 2012
Robinson James I, Carr Ian M, Cooper Dawn L, Rashid Lubna H, Martin Stephen G, Emery Paul, Isaacs John D, Barton Anne, Wilson Anthony G, Barrett Jennifer H, Morgan Ann W
Abstract excerpt
The FCGR locus encoding the low-affinity Fcγ receptors (FcγR) for immunoglobulin G has largely been missed by genome-wide association studies due to complications with structural variation and segmental duplication. Recently identified copy number variants (CNVs) affecting FCGR3A and FCGR3B have been linked to a number of autoimmune disorders. We have developed and validated a novel quantitative sequence variant...
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