Low copy numbers of FCGR3A and FCGR3B associated with Chinese patients with SLE and AASV.

doi:10.1177/0961203317700485

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Article

Low copy numbers of FCGR3A and FCGR3B associated with Chinese patients with SLE and AASV.

Lupus - 1 Nov 2017

Qi Y, Zhou X, Bu D, Hou P, Lv J, Zhang H

Abstract excerpt

Low-affinity Fcγ receptors (FcγR) act as key mediators of the pathogenic effects of autoantibodies. In this study, we aimed to determine whether copy number variations (CNVs) in FCGR3A and FCGR3B were associated with systemic lupus nephritis (SLE) and ANCA-associated systemic vasculitis (AASV) in Chinese individuals. A total of 1118 individuals were enrolled, including 415 SLE patients, 139 AASV patients, and 564...

Topics

Adult
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Case-Control Studies
DNA Copy Number Variations
Female
GPI-Linked Proteins
Genetic Predisposition to Disease
Humans
Lupus Erythematosus, Systemic
Male
Receptors, IgG

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PMID: 28355982
DOI: 10.1177/0961203317700485

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