Article
Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fcγ Receptor Region Allows Confirmation of the Association of FCGR3B Deletion with Rheumatoid Arthritis.
Human mutation - 1 Apr 2017
Rahbari Raheleh, Zuccherato Luciana W, Tischler German, Chihota Belinda, Ozturk Hasret, Saleem Sara, Tarazona-Santos Eduardo, Machado Lee R, Hollox Edward J
Abstract excerpt
Fcγ receptors are a family of cell-surface receptors that are expressed by a host of different innate and adaptive immune cells, and mediate inflammatory responses by binding the Fc portion of immunoglobulin G. In humans, five low-affinity receptors are encoded by the genes FCGR2A, FCGR2B, FCGR2C, FCGR3A, and FCGR3B, which are located in an 82.5-kb segmental tandem duplication on chromosome 1q23.3, which shows...
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