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Genetic Variation in Low-To-Medium-Affinity Fcγ Receptors: Functional Consequences, Disease Associations, and Opportunities for Personalized Medicine

3 Oct 2019

Abstract excerpt

Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). and Upon binding of complexed IgG, FcγRs can trigger various cellular immune effector functions, thereby linking the adaptive and innate immune systems. In humans, six classic FcγRs are known: one high-affinity receptor (FcγRI) and five low-to-medium-affinity FcγRs (FcγRIIA, -B and -C, FcγRIIIA and -B). In this review we describe the...

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Identifiers

PMID: 31632391
DOI: 10.3389/fimmu.2019.02237

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