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Article

Copy number, linkage disequilibrium and disease association in the FCGR locus.

Human molecular genetics - 15 Aug 2010

Niederer Heather A, Willcocks Lisa C, Rayner Tim F, Yang Wanling, Lau Yu Lung, Williams Thomas N, Scott J Anthony G, Urban Britta C, Peshu Norbert, Dunstan Sarah J, Hien Tran Tinh, Phu Nguyen Hoan, Padyukov Leonid, Gunnarsson Iva, Svenungsson Elisabet, Savage Caroline O, Watts Richard A, Lyons Paul A, Clayton David G, Smith Kenneth G C

Abstract excerpt

The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of IgG (FcgammaRs), and alterations in their affinity or function have been associated with risk of autoimmune diseases, including systemic lupus erythematosus (SLE). The low-affinity FcgammaR genomic locus is complex, containing regions of copy number variation (CNV) which can alter receptor expression and leukocyte...

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Identifiers

PMID: 20508037
DOI: 10.1093/hmg/ddq216
PMCID: PMC2908468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Copy number, linkage disequilibrium and disease association in the FCGR locus.PMID 20508037Read ↗

Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fcγ Receptor Region Allows Confirmation of the Association of FCGR3B Deletion with Rheumatoid Arthritis.Semantic proximity Read ↗

Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.Semantic proximity Read ↗

Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.Semantic proximity Read ↗

Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.Semantic proximity Read ↗

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Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus.Semantic proximity Read ↗

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