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Article

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans.

Rheumatology (Oxford, England) - 1 Jul 2011

Molokhia Mariam, Fanciulli Manuela, Petretto Enrico, Patrick Alan Leslie, McKeigue Paul, Roberts Amy L, Vyse Tim J, Aitman Tim J

Abstract excerpt

OBJECTIVES: To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry. METHODS: We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE...

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Identifiers

PMID: 21296850
DOI: 10.1093/rheumatology/keq456
PMCID: PMC3670581

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