Quantitative analysis of multiple phenotype enzyme-altered foci in rat hepatocarcinogenesis experiments: the multipath/multistage model.

doi:10.1093/carcin/16.10.2499

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Article

Quantitative analysis of multiple phenotype enzyme-altered foci in rat hepatocarcinogenesis experiments: the multipath/multistage model.

Carcinogenesis - 1 Oct 1995

Sherman C D, Portier C J

Abstract excerpt

The promotional effect of phenobarbital and 1-hydroxymethyl-pyren on enzyme altered lesions in the rat liver were quantified within the framework of two separate multipath/multistage models. The experiment analyzed followed an initiation-promotion protocol in which female Wistar rats were initiated with a single dose of diethylnitrosamine at 0.15 mumol/g body wt followed by a 3 week treatment-free period. A...

Topics

Adenosine Triphosphatases
Animals
Carcinogens
Cell Transformation, Neoplastic
Diet
Female
Liver
Liver Neoplasms, Experimental
Mathematics
Models, Biological
Phenobarbital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Precancerous Conditions

Pyrenes

Rats

Rats, Wistar

Sulfotransferases

Source

Open in PubMed

Identifiers

PMID: 7586158
DOI: 10.1093/carcin/16.10.2499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7586158-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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